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Glanders and melioidosis are related diseases produced by bacteria of the Burkholderia species, which are gram-negative rods. They produce similar symptoms and have similar pathophysiologic consequences. Glanders and melioidosis are of interest because of significant study for potential weaponization by the United States and other countries in the past. During World War I, glanders was believed to have been spread to infect large numbers of Russian horses and mules on the Eastern Front. The Japanese infected horses, civilians, and prisoners of war during World War II. The United States studied this agent as a possible biological warfare BW weapon in 1943-1944 but did not weaponize it. The former Soviet Union is believed to have been interested in glanders as a potential BW weapon as well.
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